Endocrine Abstracts

The first degree relatives of patients with diabetes type 1 have increased genetic risk of developing clinical disease. In the population of Polish diabetic subjects the most frequent alleles are HLA- DRB1*04, DRB1*03, DQA1 and DQB1. The ‘high-risk genotype’ may differ among populations.The aim of this paper was to analyze prevalence of genetic risk factors in patients with new-onset diabetes in Lower Silesia and to compare the data with Polish...

Kinases represent a main therapeutic targets in cancer treatment as their impairing is related to tumor growth and progression. Despite the increasing evidence that tumor microenvironment (TME) signaling influences the behavior of surrounding cancer epithelial cells, still little is known about what changes in stromal cells influence tumor cells’ behavior. TNBC patients are still lacking an effective therapy, as not much is known about the biology of this BC tumor subtype...

Introduction: The intricate interplay between fibroblasts and cancer cells significantly contributes to cancer invasion, extracellular matrix (ECM) modulation, and the development of drmg resistance. This study delves into understanding the specific influence of fibroblasts on Gastro-Intestinal neuroendocrine tumor (GI-NET) cell lines.Materials and Methods: Utilizing GOT1 and COLO320 cell lines, we incorporated Normal Human Dermal Fibroblasts (NF) in our...

Gastrointestinal neuroendocrine tumors (GI-NETs) present a challenging and diverse landscape, necessitating effective treatment strategies. Despite advancements, the demand for targeted therapies, particularly for advanced or metastatic cases, persists. Enhancing outcomes in GI-NETs management is crucial, emphasizing the need for ongoing research and development. In our laboratory, we conducted a multitarget compound screening, identifying FAK (BI-0319) and SYK (BI1002494) kin...

Background and Objectives: Since previously, we performed an untargeted metabolomics analysis in a cohort of morbidly obese (MO) women, in which we observed a different lipid metabolite pattern between metabolically healthy MO (MHMO) individuals and those with associated type 2 diabetes mellitus (T2DM). To validate these findings, now we have performed a complementary study of lipidomics.Materials and Methods: We assessed a liquid chromatography coupled ...

Objective: AGEs, compounds formed by the transformation of proteins, are increased in conditions of oxidative stress and promote inflammation by interacting with their receptor (RAGE) on cell membrane. By contrast, the soluble receptor for AGE (sRAGE), that is proteolytically cleaved from cell surface receptor via matrix metalloproteinases, sequester RAGE ligands and act as a cytoprotective and anti-inflammatory agent. AGEs/sRAGE interaction play a role in the pathogenesis of ...

Introduction: Intraoperative identification of neck lesions in patients who have undergone previous neck surgery is particularly difficult, because of operative scarring and distorted anatomy. Radioguided occult lesion localisation (ROLL) involves the preoperative intratumoral ultrasound-guided injection of a radioactive tracer. In the present study, we investigated the efficacy of roll in two patients with papillary thyroid cancer (PTC) who underwent previous neck exploration...

Objective: Oxidative stress has been implicated in the pathogenesis of several immune-mediated disorders, including autoimmune thyroid disease. Aim of our study was to investigate the relationship between dietary habit and redox homeostasis, in relationship with thyroid autoimmunity.Materials and methods: We enrolled 200 healthy subjects (173 F, mean age 35 ± 12). None of them was under any pharmacological treatment. Exclusion criteria: any infectio...

Introduction: Non-islet cell tumor induced hypoglycemia (NICTH) is a paraneoplastic phenomenon involving many types of tumors. It is associated with the secretion of incompletely processed precursors of IGF-2 resulting in a persistent insulin-like activity and hypoglycemia. Most commonly, IGF-2–linked hypoglycemia has been observed in patients with solid mesenchymal or epithelial tumors. Typically, elevated IGF-2 levels are associated with suppressed plasma levels of insu...

Introduction: Parathyroidectomy is the only curative treatment for primary hyperparathyroidism (pHPT) and has been traditionally performed through bilateral neck exploration (BNE). However, with the use of intraoperative parathyroid hormone (IOPTH) assay along with preoperative localization exams, minimally invasive surgery can be performed with good surgical success rate.Aim: To evaluate the usefulness of IOPTH assay in guiding adequate parathyroidectom...